When is abciximab given?
For the prevention of ischemic cardiac complications in patients undergoing PCI, and who are not currently receiving a ReoPro® infusion, the bolus should be administered 10-60 minutes prior to the intervention, followed by the infusion for twelve (12) hours.
What is ReoPro used for?
ReoPro is used to lessen the chance of heart attack in people who need percutaneous coronary intervention (PCI), a procedure to open blocked arteries of the heart. A heart attack may occur when a blood vessel in the heart is blocked by a blood clot. Blood clots can sometimes form during PCI.
Is abciximab reversible?
Currently, there is no available reversal agent. Therefore, platelet transfusion is recommended for reversing the effect of abciximab. Eptifibatide (Integrilin) is approved for use in patients with acute coronary syndrome, including patients scheduled for PCI.
What is the brand name for abciximab?
Abciximab
| Monoclonal antibody | |
|---|---|
| Trade names | Reopro |
| Other names | Abcixifiban, c7E3 Fab |
| AHFS/Drugs.com | Monograph |
| License data | US DailyMed: Abciximab US FDA: Abciximab |
What type of drug is abciximab?
Abciximab is a monoclonal anti-glycoprotein IIb/IIIa receptor antibody used to prevent thrombosis during percutaneous coronary intervention. Abciximab is a Fab fragment of the chimeric human-murine monoclonal antibody 7E3.
How is abciximab cleared?
Unbound abciximab is rapidly cleared from plasma by proteolytic degradation, resulting in a very short plasma half-life (several minutes), whereas the biological half-life ranges from 8 to 24 hours. As such, some GPIIb/IIIa receptors may still be occupied by drug up to 2 weeks after discontinuation of drug infusion.
Why is abciximab given?
USES: Abciximab is a type of “blood thinner” used to prevent blood clots during certain procedures used to open up the blood vessels in the heart (e.g., balloon angioplasty, coronary stent placement, percutaneous coronary intervention-PCI). It is usually used with heparin and aspirin.
